Year-end Sale % OFF 
Abstract
The nitrogen-bridgehead is a common structural motif present in a multitude of natural products. As many of these abundant compounds exhibit biological activities, e.g. against cancer or bacteria, these derivatives are of high interest. While natural products are often associated with problematic characteristics, such as elaborate separation processes, high molecular complexity and limited room for derivatization, purely synthetic approaches can overcome these challenges. Many synthetic procedures have been reported for preparation of artificial nitrogen bridgehead compounds, however, to our surprise only a fraction of these has been tested for their bioactivity. This review is therefore meant to give an overview of existing synthetic methods that provide scaffolds containing bridgehead nitrogen atoms, covering the period from 2000 to 2023. Reviews which cover subunits of this topic are referenced as well.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callSimilar Papers
More From: Organic & biomolecular chemistry
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
